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PIPELINE

Marketed Products

Two innovative therapies utilizing Kala’s proprietary AMPPLIFY® Drug Delivery Technology to address medical needs for front of the eye

EYSUVIS™ (loteprednol etabonate ophthalmic suspension) 0.25%

First and only prescription therapy specifically for the short-term management
of the signs and symptoms of dry eye disease

Inveltys (loteprednol etabonate ophthalmic suspension) 1% THERE IS NO GENERIC EQUIVALENT

First and only BID corticosteroid indicated for the treatment of post-operative ocular inflammation and pain

Internal Pipeline

Proprietary NCE development programs
targeted to address
front and back
of the eye diseases

Discovery Lead
Optimization
Candidate Selection Formulation Development IND-
Enabling Studies
Clinical Studies
Tyrosine Kinase Inhibitor
Retinal diseases, including wet AMD, DME, and RVO (Formulation Development)
Surface Targeting Steroid (STS)
Corneal surface diseases (Formulation Development)
Selective Glucocorticoid
Receptor
Modulator (SEGRM)
Retinal diseases, including wet AMD, DME, and RVO;
corneal surface diseases
(Lead Optimization)

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